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Communication | Special issue | Vol 54, No. 1, 2001, pp.77-80
Published online, 1st January, 1970
DOI: 10.3987/COM-00-S(I)38
Synthesis of N-Boc-3-amino-1,2-epoxy-4-phenylbutane from (3S)-Hydroxy-γ-butyrolactone by Means of the Hofmann Rearrangement

Masahiro Murakami, Kazumasa Hinoue, Kazuya Nakagawa, Yoshiko Monden, Yoshiro Furukawa, and Shigeo Katsumura*

*School of Science, Kwansei Gakuin University, Gakuen, Sanda-shi 662-8501, Japan


The stereocontrolled synthesis of the title alkylaminoepoxide was achieved starting from (3S)-hydroxy-γ-butyrolactone by efficient utilization of the Hofmann rearrangement followed by intramolecular oxazolidinone ring formation as a key step.