HETEROCYCLES

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

■ Asymmetric Pauson-khand Reactions of Chiral Sulfinamides:Å@Asymmetric Synthesis of 3-Azabicyclo[3.3.0]oct-5-en-7-one Derivatives

Kunio Hiroi* and Takashi Watanabe

*Department of Synthetic Organic Chemistry, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan

Abstract

Unprecedented asymmetric Pauson-Khand reactions of chiral sulfinamides are described. Cobalt-catalyzed reactions of chiral N-allyl-N-propargyl-N-arylsulfinamide derivatives were carried out in dichloromethane at -20°C~room temperature under carbon monoxide atmosphere in the presence of Co₂(CO)₈ to give chiral 3-azabicyclo[3.3.0]oct-5-en-7-one with moderate or low enantioselectivity.