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Communication | Special issue | Vol 54, No. 2, 2001, pp.619-622
Published online, 1st January, 1970
DOI: 10.3987/COM-00-S(I)101
An Efficient and Expeditious Synthesis of a Novel 5H-Naphth[1',2':5,6][1,4]- oxazino[2,3-b]quinoxalin-5-one and Its Unique Inhibitory Activity against a Panel of Human Cancer Cell Lines

Fusae Miyata, Sadamu Yoshida, Takao Yamori, and Tadashi Katoh*

*Sagami Chemical Research Center, Nishi-Ohnuma, Sagamihara, Kanagawa 229-0012, Japan


The title compound (1) was efficiently synthesized in two steps starting from 2,3-dichloroquinoxaline (2) and 1-amino-2-naphthol (3); the method involves cyclization of 2 with 3 and subsequent salcomine oxidation. The compound (1) showed unique inhibitory activity against a panel of human cancer cell lines.