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Communication | Regular issue | Vol 55, No. 3, 2001, pp.461-464
Published online, 1st January, 1970
DOI: 10.3987/COM-00-9142
A New Sandmeyer Iodination of 2-Aminopurines in Non-aqueous Conditions: Combination of Alkali Metal Iodide and Iodine as Iodine Sources

Naoki Ozeki,* Naoyuki Shimomura, and Hitoshi Harada

*Process Research Laboratories, Eisai Co., ltd., 22 Sunayama, Hasaki, Kashima-gun, Ibaraki 314-0255, Japan


An effective method for iodination using 2-aminopurines in non-aqueous conditions was found. The optimal conditions involved the combination of isopentyl nitrite, cuprous iodide, alkali metal iodide and iodine in ethylene glycol dimethyl ether at 60°C.