Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Regular issue | Vol 55, No. 3, 2001, pp.457-460
Published online, 1st January, 1970
DOI: 10.3987/COM-00-9135
Nucleophilic Substitution Reaction on the Nitrogen of Indole Nucleus: Formation of 1-(Indol-3-yl)indoles upon Reaction of 1-Hydroxyindoles with Indole in Formic Acid

Masanori Somei,* Fumio Yamada, Toshikatsu Hayashi, Aya Goto, and Yoshitomo Saga

*Faculty of Pharmaceutical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan


1-(Indol-3-yl)indoles are obtained in excellent to good yields by the reaction of 1-hydroxyindoles with indole in 85% formic acid. Their structures are determined by X-Ray crystallographic analysis and chemical correlations. The unprecidented SN2 mechanism on the indole nitrogen is proposed.