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Paper | Regular issue | Vol 55, No. 3, 2001, pp.535-544
Published online, 1st January, 1970
DOI: 10.3987/COM-00-9133
A Radical Synthetic Approach to the New Potentially Bioactive Pyrimidinones

Serge Djekou, Armand Gellis, José Maldonado, Michel P. Crozet, and Patrice Vanelle*

*Laboratoire de Chimie Organique, Faculté de Pharmacie, Université de la Méditerranée, 27, Boulevard Jean Moulin, 13385 Marseille Cedex 05, France

Abstract

2-Chloromethyl-8-methyl-3-nitro-4H-pyrido[1,2-a]pyrimidin-4-one was shown to react with various nitronate or malonate anions under mild conditions to give potentially bioactive nitro-4H-pyrido[1,2-a]pyrimidin-4-ones. Extension to other anions centred on S or O atom allows to generalize this synthetic procedure.