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Note | Regular issue | Vol 53, No. 10, 2000, pp.2275-2278
Published online, 1st January, 1970
DOI: 10.3987/COM-00-9003
Solvent-free Synthesis of Thio-alkylxanthines from Alkylxanthines Using Microwave Irradiation

Rodrigo Rico-Gómez,* Francisco Nájera, Juan Manuel López-Romero, and Pedro Cañada-Rudner

*Departamento de Química Orgánica, Universidad de Malága, E-29071 Malága, Spain


An expeditious, solvent-free procedure for the conversion of the xanthine bases theophylline, 8-methyltheophylline, caffeine, and theobromine to the corresponding 6-thio and 2,6-dithio derivatives using Lawesson’s reagent under microwave irradiation is proposed.