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Note | Regular issue | Vol 53, No. 10, 2000, pp.2253-2259
Published online, 1st January, 1970
DOI: 10.3987/COM-00-8998
First Total Syntheses of (+)-Polyoxin B and (+)-Polyoxin D

Kimio Uchida, Keisuke Kato, Kentaro Yamaguchi, and Hiroyuki Akita*

*School of Pharmaceutical Sciences, Toho University, 2-2-1, Miyama, Funabashi, Chiba 274-8510, Japan


First total syntheses of the peptidyl nucleoside antibiotics, polyoxins B (1) and D (2), are achieved based on the coupling reactions of the N-protected L-carbamoyl-polyoxamic acid derivative (6) with polyoxin C (8), 6 with polyoxin C acid (9), respectively.