HETEROCYCLES

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

■ New Synthesis of KT5823 Indolocarbazole Aglycone

Guillaume E. Burtin,* Daivd J. Madge,* and David L. Selwood

*The Wolfson Institute for Biomedicinal Reseach, Biological and Medicinal Chemsitry, University College London, Cruciform Building, Gower Street, London, WC1E 6AU, U.K.

Abstract

The indolo[2,3-a]pyrrolo[3,4-c]carbazole aglycone of the selective protein kinase G inhibitor KT5823 has been synthesised in four steps and 36% overall yield from 2,3-dichloro-N-methylmaleimide by utilising an efficient new two step reduction sequence for the key imide to amide transformation.