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Communication | Regular issue | Vol 53, No. 8, 2000, pp.1681-1684
Published online, 1st January, 1970
DOI: 10.3987/COM-00-8940
Total Synthesis of Antioxidant Alkaloid Carazostatin via Electrocyclic Ring Closure of 3-Butadienyl-2-methoxyindole

Yoshinori Nonaka,* Tomomi Kawasaki, and Masanori Sakamoto*

*Kissei Pharmaceutical Co., LTD., 4365-1 Kashiwabara, Hotaka, Minamiazumi, Nagano 399-8304, Japan


Total synthesis of the naturally occurring antioxidant carazostatin was accomplished by an efficient method, Wittig reaction of 2-methoxyindol-3-one followed by electrocyclic reaction of 3-(1,3-butadienyl)indole.