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Communication | Regular issue | Vol 53, No. 8, 2000, pp.1677-1680
Published online, 1st January, 1970
DOI: 10.3987/COM-00-8932
A Diamine-Exchange Reaction of Dihydropyrazines

Tadatoshi Yamaguchi,* Shigeru Ito, Yukiko Iwase, Kenji Watanabe, and Kazunobu Harano

*Department of Hygiene, Miyazaki Medical College, Kiyotake-cho, Miyazaki 889-1601, Japan

Abstract

Dihydropyrazines reacted with 1,2-diamines to form tetraazadecalins as intermediates, and then the reaction proceeded forward to dissociate into alternate dihydropyrazine and diamine, or backward to dissociate into the starting materials in certain equilibrium. The product distribution is controlled by diamine-exchange equilibrium reaction. The various equilibrium reactions were analyzed by NMR spectroscopy .