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Communication | Regular issue | Vol 53, No. 7, 2000, pp.1479-1483
Published online, 1st January, 1970
DOI: 10.3987/COM-00-8913
β-Lactam Synthesis by Diastereoselective Condensation of Chiral 3-(p-Tolylsulfinyl)-2-furaldimine and Ester Enolates

Yoshitsugu Arai,* Shinya Yoneda, Tsutomu Masuda, and Yukio Masaki

*Gifu Pharmaceutical University, 6-1 Mitahora-higashi 5-chome, Gifu 502-8585, Japan


Highly diastereoselective condensation of chiral sulfinyl-substituted furaldimine with lithium ester enolates has been achieved, affording (3R)-syn-β-lactams and/or (3R)-syn-β-amino esters, as the major products