Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Note | Regular issue | Vol 53, No. 7, 2000, pp.1569-1572
Published online, 1st January, 1970
DOI: 10.3987/COM-00-8894
A Synthesis of Cytonin (Taiwanin A), an Antitumor Lignan

Weir-Torn Jiaang, Chih-Liang Wang, Albert Tseng, and Shui-Tein Chen*

*Institute of Biological Chemistry, Academia Sinica, Taipei, 115, Taiwan, R.O.C.


A new procedure for the synthesis of the antitumor substance: cytonin (taiwanin A) is described. Stobbe reaction, using diethyl succinate with piperonal in a 2:1 molar ratio, produced 2E,3E-dipiperonylidenesuccinic acid. Dehydration to the anhydride, followed by reduction with DIBALH gave hydroxy acid. Subsequent cyclization of the hydroxy acid resulted in 21% total yield of cytonin.