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Communication | Regular issue | Vol 53, No. 6, 2000, pp.1255-1258
Published online, 1st January, 1970
DOI: 10.3987/COM-00-8888
Synthesis of 3a-(Indol-3-yl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b ]indole Core of Leptosins D-F Based on Nucleophilic Substitution Reaction on Indole Nucleus

Fumio Yamada, Aya Goto, and Masanori Somei*

*Faculty of Pharmaceutical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan

Abstract

A simple and convenient synthetic methodology for 3a-(indol-3-yl)- 1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole, the core structure of leptosins D–F is developed by applying nucleophilic substitution reaction of 1-hydroxytryptamines.