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Paper | Regular issue | Vol 53, No. 6, 2000, pp.1317-1328
Published online, 1st January, 1970
DOI: 10.3987/COM-00-8884
Solution Parallel Synthesis of Cyclic Guanidines

Christelle Marmillon, Jacques Bompart, Michèle Calas, Roger Escale,* and Pierre-Antoine Bonnet

*E. A. 2414 Pharmacochimie et Biomolécules, UFR Sciences Pharmaceutiques et Biologiques, 15, av. C. Flahault, 34060 Montpellier cedex 2, France

Abstract

An efficient method for the solution phase synthesis of cyclic guanidines is presented. A variety of 2-substituted monoprotected propanediamines react with a set of 5-substituted 2-methylthio-3,4,5,6-tetrahydropyrimidines under Rathke conditions for the construction of a potential library of 81 cyclic guanidines.