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■ A Novel Convenient Synthesis of 1,3,5,5-Tetrasubstituted Hexahydropyrimidine-4-thiones

Juraj Bernát, Pavol Kristian,* Janka Guspanová, and Igor Chomca

*Department of Organic Chemistry, P. J. Safárik University, 04167 Kosice, Slovakia

Abstract

Sodium salts of (2-substituted thiocarbamoyl)malonic acid diethyl esters (2a-d) obtained via reaction of isothiocyanates (1a-d) with sodium diethyl malonate afforded with formaldehyde and amine sulfate in water medium diethyl 1,3-disubstituted 4-thioxohexahydropyrimidine-5,5-dicarboxylates (3a-j). Reaction represents the simple and convenient way to synthesize the title compounds.