HETEROCYCLES

An International Journal for Reviews and Communications in Heterocyclic Chemistry
Web Edition ISSN: 1881-0942
Published online by The Japan Institute of Heterocyclic Chemistry

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Search65,753 Compounds

Nomenclature:

The natural products are listed under the name used in the original literature.

The abbreviations:

The following abbreviations have been used:

• act:
• biological activity

• cd:
• circular dichroism

• Cnmr:
• 13C-nuclear magnetic resonance spectrum

• Hnmr:
• 1H-nuclear magnetic resonance spectrum

• ir:
• infrared spectrum

• mass:
• mass spectrum

• syn:
• total synthesis

• uv:
• ultraviolet spectrum

Journal:

This database lists the natural products with heterocyclic ring system whose synthesis has been determined since 1975. The journals which have been covered are as follows:

Angew. Chem. Int. Ed. Engl.
Angew. Chem. Int. Ed.
Bull. Chem. Soc. Japan
Chem. and Ind.
Chem. Ber.
J. Chem. Soc., Chem. Commun.
Chem. Commun.
Chem. Eur. J.
Chemistry Lett.
Chem. Pharm. Bull.
Coll. Czech. Chem. Commun.
Eur. J. Inorg. Chem.
Eur. J. Org. Chem.
Experientia
Helv. Chim. Acta
Heterocycles
J. Am. Chem. Soc.
J. Antibiot.
J. Chem. Soc., Perkin Trans. 1
J. Heterocycl. Chem.
J. Med. Chem.
J. Nat. Prod.
J. Org. Chem.
J. Pharm. Sci.
Liebigs Ann. Chem.
Monatsh. Chem.
Org. Lett.
Phytochemistry
Planta medica
Synlett
Synth. Commun.
Synthesis
Tetrahedron
Tetrahedron Asymmetry
Tetrahedron Lett.
Yakugaku Zasshi

Editor:

Editor:
Kunio Ogasawara

Associate Editors:
Toshio Honda
Yoshiharu Iwabuchi

This journal will list the new natural products with a heterocyclic ring system, collected from current chemical literature, whose structure has been established.

• Search by Group: AllPolyketidesAromaticsTerpenesSteroidsAlkaloidsAntibioticsMiscellaneous
• Search by Journal: Chem. Pharm. Bull.Helv. Chim. ActaHeterocyclesJ. Antibiot.J. Nat. Prod.J. Org. Chem.Org. Biomol. Chem.Org. Lett.Phytochem. Lett.PhytochemistryPlanta medicaTetrahedronTetrahedron Lett.
• Year: 2014201420142014201420142014201420142014201420142014
• Vol: 6297896777791216107107807055
• No: 11111111112143, 4421, 22  1744-4745-48

Polyketides

Aspergillusol A

C12H12O5 = 236

J. Nat. Prod. 2014, 77, 2375

V. Rukachaisirikul, N. Rungsaiwattana, S. Klaiklay, S. Phongpaichit, K. Borwornwiriyapan, J. Sakayaroj

DOI: 10.1021/np500324b

CrossRef

[	NS	]	Aspergillus species PSU-RSPG185
[	mp	]
[	bp	]
[	α	] D	- 4.6   [ MeOH ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]

Polyketides

Aspergillusol B

C12H12O5 = 236

J. Nat. Prod. 2014, 77, 2375

V. Rukachaisirikul, N. Rungsaiwattana, S. Klaiklay, S. Phongpaichit, K. Borwornwiriyapan, J. Sakayaroj

DOI: 10.1021/np500324b

CrossRef

[	NS	]	Aspergillus species PSU-RSPG185
[	mp	]
[	bp	]
[	α	] D
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]

Polyketides

Cryptolactone A1

C18H30O4 = 310

J. Nat. Prod. 2014, 77, 2459

M. Horikawa, M. Inai, Y. Oguri, E. Kuroda, M. Tanaka, S. Suzuki, T. Ito, S Takahashi, H. Kaku, T. Tsunoda

DOI: 10.1021/np500542x

CrossRef

[	NS	]	Cryptomyzus species
[	mp	]
[	bp	]
[	α	] D	- 53.5   [ CHCl3 ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	cytotoxicity

Polyketides

Cryptolactone A2

C18H30O4 = 310

J. Nat. Prod. 2014, 77, 2459

M. Horikawa, M. Inai, Y. Oguri, E. Kuroda, M. Tanaka, S. Suzuki, T. Ito, S Takahashi, H. Kaku, T. Tsunoda

DOI: 10.1021/np500542x

CrossRef

[	NS	]	Cryptomyzus species
[	mp	]
[	bp	]
[	α	] D	- 44.1   [ CHCl3 ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	cytotoxicity

Polyketides

Cryptolactone B1

C20H34O4 = 338

J. Nat. Prod. 2014, 77, 2459

M. Horikawa, M. Inai, Y. Oguri, E. Kuroda, M. Tanaka, S. Suzuki, T. Ito, S Takahashi, H. Kaku, T. Tsunoda

DOI: 10.1021/np500542x

CrossRef

[	NS	]	Cryptomyzus species
[	mp	]
[	bp	]
[	α	] D	- 46.1   [ CHCl3 ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	cytotoxicity

Polyketides

Cryptolactone B2

C20H34O4 = 338

J. Nat. Prod. 2014, 77, 2459

M. Horikawa, M. Inai, Y. Oguri, E. Kuroda, M. Tanaka, S. Suzuki, T. Ito, S Takahashi, H. Kaku, T. Tsunoda

DOI: 10.1021/np500542x

CrossRef

[	NS	]	Cryptomyzus species
[	mp	]
[	bp	]
[	α	] D
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	cytotoxicity

Polyketides

Borrelidin B

C28H47NO6 = 493

J. Nat. Prod. 2014, 77, 2570

C. J. Schulze, W. M. Bray, F. Loganzo, M.-H. Lam, T. Szal, A. Villalobos, F. E. Koehn, R. G. Linington

DOI: 10.1021/np500727g

CrossRef

[	NS	]	Streptomyces species
[	mp	]
[	bp	]
[	α	] D	+ 26.2   [ MeOH ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	growth inhibit activity

Polyketides

Azaspiracid-33

C41H65NO9 = 715

J. Nat. Prod. 2014, 77, 2465

J. Kilcoyne, C. Nulty, T. Jauffrais, P. McCarron, F. Herve, B. Foley, F. Rise, S. Crain, A. L. Wilkins, M. J. Twiner, P. Hess, C. O. Miles

DOI: 10.1021/np500555k

CrossRef

[	NS	]	Azadinium spinosum
[	mp	]
[	bp	]
[	α	] D
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	cytotoxicity

Polyketides

Azaspiracid-34

C45H69NO12 = 815

J. Nat. Prod. 2014, 77, 2465

J. Kilcoyne, C. Nulty, T. Jauffrais, P. McCarron, F. Herve, B. Foley, F. Rise, S. Crain, A. L. Wilkins, M. J. Twiner, P. Hess, C. O. Miles

DOI: 10.1021/np500555k

CrossRef

[	NS	]	Azadinium spinosum
[	mp	]
[	bp	]
[	α	] D
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	cytotoxicity

Aromatics

Cudracuspiphenone B

C18H16O5 = 312

J. Nat. Prod. 2014, 77, 2361

Y. H. Jo, B. Shin, Q. Liu, K. Y. Lee, D.-C. Oh, B. Y. Hwang, M. K. Lee

DOI: 10.1021/np5002797

CrossRef

[	NS	]	Cudrania tricuspidata
[	mp	]
[	bp	]
[	α	] D
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	antiproliferative activity

Aromatics

Pteroloterin A

C22H26O5 = 370

J. Nat. Prod. 2014, 77, 2432

J. Suthiwong, S. Pitchuanchom, W. Wattanawongdon, C. Hahnvajanawong, C. Yenjai

DOI: 10.1021/np500476h

CrossRef

[	NS	]	Pterolobium macropterum
[	mp	]	148 - 150 ℃
[	bp	]
[	α	] D	+ 51   [ CHCl3 ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	cytotoxicity

Aromatics

Pteroloterin B

C22H28O5 = 372

J. Nat. Prod. 2014, 77, 2432

J. Suthiwong, S. Pitchuanchom, W. Wattanawongdon, C. Hahnvajanawong, C. Yenjai

DOI: 10.1021/np500476h

CrossRef

[	NS	]	Pterolobium macropterum
[	mp	]
[	bp	]
[	α	] D	+ 24   [ CHCl3 ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	cytotoxicity

Aromatics

Cudracuspixanthone B

C23H22O6 = 394

J. Nat. Prod. 2014, 77, 2361

Y. H. Jo, B. Shin, Q. Liu, K. Y. Lee, D.-C. Oh, B. Y. Hwang, M. K. Lee

DOI: 10.1021/np5002797

CrossRef

[	NS	]	Cudrania tricuspidata
[	mp	]
[	bp	]
[	α	] D	- 83   [ MeOH ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	antiproliferative activity

Aromatics

Taepeenin C, 1β-Acetoxy

C28H28O6 = 400

J. Nat. Prod. 2014, 77, 2432

J. Suthiwong, S. Pitchuanchom, W. Wattanawongdon, C. Hahnvajanawong, C. Yenjai

DOI: 10.1021/np500476h

CrossRef

[	NS	]	Pterolobium macropterum
[	mp	]	179 - 183 ℃
[	bp	]
[	α	] D	- 60   [ CHCl3 ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]

Aromatics

Cudracuspixanthone A

C24H26O6 = 410

J. Nat. Prod. 2014, 77, 2361

Y. H. Jo, B. Shin, Q. Liu, K. Y. Lee, D.-C. Oh, B. Y. Hwang, M. K. Lee

DOI: 10.1021/np5002797

CrossRef

[	NS	]	Cudrania tricuspidata
[	mp	]
[	bp	]
[	α	] D
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	antiproliferative activity

Aromatics

Cudracuspixanthone C

C24H26O6 = 410

J. Nat. Prod. 2014, 77, 2361

Y. H. Jo, B. Shin, Q. Liu, K. Y. Lee, D.-C. Oh, B. Y. Hwang, M. K. Lee

DOI: 10.1021/np5002797

CrossRef

[	NS	]	Cudrania tricuspidata
[	mp	]
[	bp	]
[	α	] D	- 206   [ MeOH ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	antiproliferative activity

Aromatics

Cudracuspixanthone D

C24H26O6 = 410

J. Nat. Prod. 2014, 77, 2361

Y. H. Jo, B. Shin, Q. Liu, K. Y. Lee, D.-C. Oh, B. Y. Hwang, M. K. Lee

DOI: 10.1021/np5002797

CrossRef

[	NS	]	Cudrania tricuspidata
[	mp	]
[	bp	]
[	α	] D	+ 96   [ MeOH ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	antiproliferative activity

Aromatics

No Name

C25H30O5 = 410

J. Nat. Prod. 2014, 77, 2418

M. C. de M. Burger, J. B. Fernandes, M. F. das G. F. da Silva, A. Escalante, J. Prudhomme, K. G. L. Roch, M. A. Izidoro, P. C. Vieira

DOI: 10.1021/np500453x

CrossRef

[	NS	]	Metrodorea stipularis
[	mp	]
[	bp	]
[	α	] D
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	growth inhibit activity

Aromatics

No Name

C25H30O5 = 410

J. Nat. Prod. 2014, 77, 2418

M. C. de M. Burger, J. B. Fernandes, M. F. das G. F. da Silva, A. Escalante, J. Prudhomme, K. G. L. Roch, M. A. Izidoro, P. C. Vieira

DOI: 10.1021/np500453x

CrossRef

[	NS	]	Metrodorea stipularis
[	mp	]
[	bp	]
[	α	] D
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]

Aromatics

Notoincisol B

C28H34O3 = 418

J. Nat. Prod. 2014, 77, 2513

X. Liu, O. Kunert, M. Blunder, N. Fakhrudin, S. M. Noha, C. Malainer, A. Schinkovitz, E. H. Heiss, A. G. Atanasov, M. Kollroser, D. Schuster, V. M. Dirsch, R. Bauer

DOI: 10.1021/np500605v

CrossRef

[	NS	]	Notopterygium incisum
[	mp	]
[	bp	]
[	α	] D	+ 268.9   [ MeOH ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	inhibition of NO production

Aromatics

Notoincisol C

C27H32O4 = 420

J. Nat. Prod. 2014, 77, 2513

X. Liu, O. Kunert, M. Blunder, N. Fakhrudin, S. M. Noha, C. Malainer, A. Schinkovitz, E. H. Heiss, A. G. Atanasov, M. Kollroser, D. Schuster, V. M. Dirsch, R. Bauer

DOI: 10.1021/np500605v

CrossRef

[	NS	]	Notopterygium incisum
[	mp	]
[	bp	]
[	α	] D	+ 25.8   [ MeOH ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]

Aromatics

No Name

C30H38O5 = 478

J. Nat. Prod. 2014, 77, 2418

M. C. de M. Burger, J. B. Fernandes, M. F. das G. F. da Silva, A. Escalante, J. Prudhomme, K. G. L. Roch, M. A. Izidoro, P. C. Vieira

DOI: 10.1021/np500453x

CrossRef

[	NS	]	Metrodorea stipularis
[	mp	]
[	bp	]
[	α	] D
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	growth inhibit activity

Aromatics

Karwinaphthopyranone B2

C32H30O7 = 526

J. Nat. Prod. 2014, 77, 2404

C. Rojas-Flores, M. Y. Rios, R. López-Marure, H. F. Olivo

DOI: 10.1021/np500430q

CrossRef

[	NS	]	Karwinskia parvifolia
[	mp	]
[	bp	]
[	α	] D	+ 141.5   [ CHCl3 ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]

Aromatics

Karwinaphthopyranone B3

C32H28O8 = 540

J. Nat. Prod. 2014, 77, 2404

C. Rojas-Flores, M. Y. Rios, R. López-Marure, H. F. Olivo

DOI: 10.1021/np500430q

CrossRef

[	NS	]	Karwinskia parvifolia
[	mp	]
[	bp	]
[	α	] D	+ 136.9   [ CHCl3 ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]

Aromatics

Karwinaphthopyranone B1

C32H32O8 = 544

J. Nat. Prod. 2014, 77, 2404

C. Rojas-Flores, M. Y. Rios, R. López-Marure, H. F. Olivo

DOI: 10.1021/np500430q

CrossRef

[	NS	]	Karwinskia parvifolia
[	mp	]
[	bp	]
[	α	] D	- 37.4   [ CHCl3 ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	cytotoxicity

Aromatics

Karwinaphthopyranone A2

C33H30O9 = 570

J. Nat. Prod. 2014, 77, 2404

C. Rojas-Flores, M. Y. Rios, R. López-Marure, H. F. Olivo

DOI: 10.1021/np500430q

CrossRef

[	NS	]	Karwinskia parvifolia
[	mp	]
[	bp	]
[	α	] D	+ 138.4   [ CHCl3 ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]

Aromatics

Karwinaphthopyranone A1

C33H34O9 = 574

J. Nat. Prod. 2014, 77, 2404

C. Rojas-Flores, M. Y. Rios, R. López-Marure, H. F. Olivo

DOI: 10.1021/np500430q

CrossRef

[	NS	]	Karwinskia parvifolia
[	mp	]
[	bp	]
[	α	] D	+ 147.3   [ CHCl3 ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]

Terpenes

No Name

C20H30O4 = 334

J. Nat. Prod. 2014, 77, 2342

Z.-Y. Wu, Y.-B. Zhang, K.-K. Zhu, C. Luo, J.-X. Zhang, C.-R. Cheng, R.-H. Feng, W.-Z. Yang, F. Zeng, Y. Wang, P.-P. Xu, J.-L. Guo, X. Liu, S.-H. Guan, D.-A. Guo

DOI: 10.1021/np500125x

CrossRef

[	NS	]	Acanthopanax gracilistylus
[	mp	]
[	bp	]
[	α	] D	- 24   [ MeOH ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	inhibit effect of IL-8

Terpenes

Swielimonoid A

C32H38O9 = 566

J. Nat. Prod. 2014, 77, 2367

Y.-B. Cheng, Y.-T. Chien, J.-C. Lee, C.-K. Tseng, H.-C. Wang, I-W. Lo, Y.-H. Wu, S.-Y. Wang, Y.-C. Wu, F.-R. Chang

DOI: 10.1021/np5002829

CrossRef

[	NS	]	Swietenia macrophylla
[	mp	]
[	bp	]
[	α	] D	+ 23   [ CH2Cl2 ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]

Terpenes

Swielimonoid B

C32H42O10 = 586

J. Nat. Prod. 2014, 77, 2367

Y.-B. Cheng, Y.-T. Chien, J.-C. Lee, C.-K. Tseng, H.-C. Wang, I-W. Lo, Y.-H. Wu, S.-Y. Wang, Y.-C. Wu, F.-R. Chang

DOI: 10.1021/np5002829

CrossRef

[	NS	]	Swietenia macrophylla
[	mp	]
[	bp	]
[	α	] D	- 52   [ CH2Cl2 ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	cytotoxicity

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