HETEROCYCLES

An International Journal for Reviews and Communications in Heterocyclic Chemistry
Web Edition ISSN: 1881-0942
Published online by The Japan Institute of Heterocyclic Chemistry

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Search65,753 Compounds

Nomenclature:

The natural products are listed under the name used in the original literature.

The abbreviations:

The following abbreviations have been used:

• act:
• biological activity

• cd:
• circular dichroism

• Cnmr:
• 13C-nuclear magnetic resonance spectrum

• Hnmr:
• 1H-nuclear magnetic resonance spectrum

• ir:
• infrared spectrum

• mass:
• mass spectrum

• syn:
• total synthesis

• uv:
• ultraviolet spectrum

Journal:

This database lists the natural products with heterocyclic ring system whose synthesis has been determined since 1975. The journals which have been covered are as follows:

Angew. Chem. Int. Ed. Engl.
Angew. Chem. Int. Ed.
Bull. Chem. Soc. Japan
Chem. and Ind.
Chem. Ber.
J. Chem. Soc., Chem. Commun.
Chem. Commun.
Chem. Eur. J.
Chemistry Lett.
Chem. Pharm. Bull.
Coll. Czech. Chem. Commun.
Eur. J. Inorg. Chem.
Eur. J. Org. Chem.
Experientia
Helv. Chim. Acta
Heterocycles
J. Am. Chem. Soc.
J. Antibiot.
J. Chem. Soc., Perkin Trans. 1
J. Heterocycl. Chem.
J. Med. Chem.
J. Nat. Prod.
J. Org. Chem.
J. Pharm. Sci.
Liebigs Ann. Chem.
Monatsh. Chem.
Org. Lett.
Phytochemistry
Planta medica
Synlett
Synth. Commun.
Synthesis
Tetrahedron
Tetrahedron Asymmetry
Tetrahedron Lett.
Yakugaku Zasshi

Editor:

Editor:
Kunio Ogasawara

Associate Editors:
Toshio Honda
Yoshiharu Iwabuchi

This journal will list the new natural products with a heterocyclic ring system, collected from current chemical literature, whose structure has been established.

• Search by Group: AllPolyketidesAromaticsTerpenesSteroidsAlkaloidsAntibioticsMiscellaneous
• Search by Journal: Chem. Pharm. Bull.Helv. Chim. ActaHeterocyclesJ. Antibiot.J. Nat. Prod.J. Org. Chem.Org. Biomol. Chem.Org. Lett.Phytochem. Lett.PhytochemistryPlanta medicaTetrahedronTetrahedron Lett.
• Year: 2014201420142014201420142014201420142014201420142014
• Vol: 6297896777791216107107807055
• No: 11111111112143, 4421, 22  1744-4745-48

Alkaloids

No Name

C10H5NO3 = 187

Tetrahedron Lett. 2014, 55, 6530

D.-B. Hu, W.-X. Li, Z.-Z. Zhao, T. Feng, R.-H. Yin, Z.-H. Li, J.-K. Liu, H.-J. Zhu

DOI: 10.1016/j.tetlet.2014.09.132

CrossRef

[	NS	]	Junghuhnianitida
[	mp	]
[	bp	]
[	α	] D
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	cytotoxic activity

Alkaloids

Sorazinone A

C11H8N2O2 = 200

J. Nat. Prod. 2014, 77, 2545

R. Jansen, S. Sood, K. I. Mohr, B. Kunze, H. Irschik, M. Stadler, R. Müller

DOI: 10.1021/np500632c

CrossRef

[	NS	]	Nannocystis pusilla
[	mp	]
[	bp	]
[	α	] D
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]

Alkaloids

Hosieine C

C14H18N2O = 230

Phytochemistry 2014, 107, 97

I. Pouny, M. Batut, L. Vendier, B. David, S. Yi, F. Sautel, P. B. Arimondo, G. Massiot

DOI: 10.1016/j.phytochem.2014.07.022

CrossRef

[	NS	]	Ormosia hosiei
[	mp	]
[	bp	]
[	α	] D	- 31   [ MeOH ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	affinity for nicotinic acetylcholine receptor α2β4 subtype

Alkaloids

Nannozinone A

C15H16N2O = 240

J. Nat. Prod. 2014, 77, 2545

R. Jansen, S. Sood, K. I. Mohr, B. Kunze, H. Irschik, M. Stadler, R. Müller

DOI: 10.1021/np500632c

CrossRef

[	NS	]	Nannocystis pusilla
[	mp	]
[	bp	]
[	α	] D
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	antibacterial and antifungal activity

Alkaloids

Hosieine A

C15H20N2O = 244

Phytochemistry 2014, 107, 97

I. Pouny, M. Batut, L. Vendier, B. David, S. Yi, F. Sautel, P. B. Arimondo, G. Massiot

DOI: 10.1016/j.phytochem.2014.07.022

CrossRef

[	NS	]	Ormosia hosiei
[	mp	]	139 ℃
[	bp	]
[	α	] D	- 122   [ MeOH ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	affinity for nicotinic acetylcholine receptor α2β4 subtype

Alkaloids

Hosieine B

C15H20N2O2 = 260

Phytochemistry 2014, 107, 97

I. Pouny, M. Batut, L. Vendier, B. David, S. Yi, F. Sautel, P. B. Arimondo, G. Massiot

DOI: 10.1016/j.phytochem.2014.07.022

CrossRef

[	NS	]	Ormosia hosiei
[	mp	]
[	bp	]
[	α	] D	- 106   [ MeOH ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	affinity for nicotinic acetylcholine receptor α2β4 subtype

Alkaloids

Hosieine D

C15H20N2O2 = 260

Phytochemistry 2014, 107, 97

I. Pouny, M. Batut, L. Vendier, B. David, S. Yi, F. Sautel, P. B. Arimondo, G. Massiot

DOI: 10.1016/j.phytochem.2014.07.022

CrossRef

[	NS	]	Ormosia hosiei
[	mp	]
[	bp	]
[	α	] D	- 52   [ MeOH ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	affinity for nicotinic acetylcholine receptor α2β4 subtype

Alkaloids

Nannozinone B

C16H14N2O2 = 266

J. Nat. Prod. 2014, 77, 2545

R. Jansen, S. Sood, K. I. Mohr, B. Kunze, H. Irschik, M. Stadler, R. Müller

DOI: 10.1021/np500632c

CrossRef

[	NS	]	Nannocystis pusilla
[	mp	]
[	bp	]
[	α	] D
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	growth inhibit activity

Alkaloids

Sallisonine D

C16H17NO3 = 271

Tetrahedron 2014, 70, 8893

Y.-H. Li, H.-M. Li, Y. Li, J. He, X. Deng, L.-Y. Peng, L.-H. Gao, Q.-S. Zhao, R.-T. Li, X.-D. Wu

DOI: 10.1016/j.tet.2014.09.088

CrossRef

[	NS	]	Sinomenium acutum
[	mp	]
[	bp	]
[	α	] D	- 21.8   [ CHCl3 ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]

Alkaloids

Evollionine C

C16H19NO3 = 273

Helv. Chim. Acta 2014, 97, 1481

Y.-H. Li, J. He, Y. Li, X.-D. Wu, L.-Y. Peng, R.-N. Du, X. Cheng, Q.-S. Zhao, R.-T. Li

DOI: 10.1002/hlca.201300449

CrossRef

[	NS	]	Evodia rutaecarpa
[	mp	]
[	bp	]
[	α	] D	– 5.26   [ MeOH ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]

Alkaloids

Sorazinone B

C19H18N2O = 290

J. Nat. Prod. 2014, 77, 2545

R. Jansen, S. Sood, K. I. Mohr, B. Kunze, H. Irschik, M. Stadler, R. Müller

DOI: 10.1021/np500632c

CrossRef

[	NS	]	Nannocystis pusilla
[	mp	]
[	bp	]
[	α	] D
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]

Alkaloids

Alstoscholarisine A

C19H24N2O = 296

Org. Lett. 2014, 16, 5808

X.-W. Yang, C.-P. Yang, L.-P. Jiang, X.-J. Qin, Y.-P. Liu, Q.-S. Shen, Y.-B. Chen, X.-D. Luo

DOI: 10.1021/ol5029223

CrossRef

[	NS	]	Alstonia scholaris
[	mp	]	151 - 152 ℃
[	bp	]
[	α	] D	- 184.6   [ MeOH ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	promoting effect on adult neuronal stem cell proliferation

Alkaloids

Alstoscholarisine E

C19H24N2O = 296

Org. Lett. 2014, 16, 5808

X.-W. Yang, C.-P. Yang, L.-P. Jiang, X.-J. Qin, Y.-P. Liu, Q.-S. Shen, Y.-B. Chen, X.-D. Luo

DOI: 10.1021/ol5029223

CrossRef

[	NS	]	Alstonia scholaris
[	mp	]	138 - 140 ℃
[	bp	]
[	α	] D	- 340.7   [ MeOH ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	promoting effect on adult neuronal stem cell proliferation

Alkaloids

Eburnamonine, 19-Oxo-

C19H20N2O2 = 308

Tetrahedron 2014, 70, 9099

M. Kitajima, M. Anbe, N. Kogure, S. Wongseripipatana, H. Takayama

DOI: 10.1016/j.tet.2014.10.002

CrossRef

[	NS	]	Kopsia jasminiflora
[	mp	]
[	bp	]
[	α	] D	- 115   [ CHCl3 ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]

Alkaloids

Vincamone, 19S-Hydroxy-Δ14-

C19H20N2O2 = 308

Tetrahedron 2014, 70, 9099

M. Kitajima, M. Anbe, N. Kogure, S. Wongseripipatana, H. Takayama

DOI: 10.1016/j.tet.2014.10.002

CrossRef

[	NS	]	Kopsia jasminiflora
[	mp	]
[	bp	]
[	α	] D	+ 27   [ CHCl3 ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	inhibitory activity toward A549, HT29, HCT116

Alkaloids

Tacamonine-N-oxide

C19H22N2O2 = 310

J. Nat. Prod. 2014, 77, 2504

D. S.-Y. Sim, K.-W. Chong, C.-E Nge, Y.-Y. Low, K.-S. Sim, T.-S. Kam

DOI: 10.1021/np500589u

CrossRef

[	NS	]	Tabernaemontana
[	mp	]
[	bp	]
[	α	] D	+ 25   [ CHCl3 ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]

Alkaloids

Salvadenosine

C11H15N5O4S = 313

J. Org. Chem. 2014, 79, 9992

M. T. Jamison, C. N. Boddy, T. F. Molinski

DOI: 10.1021/jo501486p

CrossRef

[	NS	]	Didemnum species
[	mp	]
[	bp	]
[	α	] D	+ 11.3   [ MeOH ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]

Alkaloids

Evollionine A

C19H15N3O2 = 317

Helv. Chim. Acta 2014, 97, 1481

Y.-H. Li, J. He, Y. Li, X.-D. Wu, L.-Y. Peng, R.-N. Du, X. Cheng, Q.-S. Zhao, R.-T. Li

DOI: 10.1002/hlca.201300449

CrossRef

[	NS	]	Evodia rutaecarpa
[	mp	]	167.9 - 169.2 ℃
[	bp	]
[	α	] D	– 6.4   [ MeOH ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]

Alkaloids

Vincamajorine A

C20H20N2O2 = 320

Tetrahedron Lett. 2014, 55, 6490

Z.-J. Zhang, J. Yang, J. He, X.-D. Wu, L.-D. Shao, Y. Li, S.-X. Huang, R.-T. Li, Q.-S. Zhao

DOI: 10.1016/j.tetlet.2014.10.011

CrossRef

[	NS	]	Vinca major
[	mp	]
[	bp	]
[	α	] D	– 13.04   [ MeOH ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]

Alkaloids

Sallisonine E

C19H15NO4 = 321

Tetrahedron 2014, 70, 8893

Y.-H. Li, H.-M. Li, Y. Li, J. He, X. Deng, L.-Y. Peng, L.-H. Gao, Q.-S. Zhao, R.-T. Li, X.-D. Wu

DOI: 10.1016/j.tet.2014.09.088

CrossRef

[	NS	]	Sinomenium acutum
[	mp	]
[	bp	]
[	α	] D	- 22.4   [ CHCl3 ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]

Alkaloids

Vincamajorine B

C20H22N2O2 = 322

Tetrahedron Lett. 2014, 55, 6490

Z.-J. Zhang, J. Yang, J. He, X.-D. Wu, L.-D. Shao, Y. Li, S.-X. Huang, R.-T. Li, Q.-S. Zhao

DOI: 10.1016/j.tetlet.2014.10.011

CrossRef

[	NS	]	Vinca major
[	mp	]
[	bp	]
[	α	] D	– 114.40   [ MeOH ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]

Alkaloids

Vinmajine I

C20H17N3O2 = 331

Tetrahedron 2014, 70, 8723

G.-G. Cheng, Y.-L. Zhao, Y. Zhang, P.-K. Lunga, D.-B. Hu, Y. Li, J. Gu, C.-W. Song, W.-B. Sun, Y.-P. Liu, X.-D. Luo

DOI: 10.1016/j.tet.2014.09.026

CrossRef

[	NS	]	Vinca major
[	mp	]
[	bp	]
[	α	] D	+ 31.7   [ MeOH ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]

Alkaloids

Kopsinic Acid, 5-Oxo-

C20H22N2O3 = 338

Tetrahedron 2014, 70, 9099

M. Kitajima, M. Anbe, N. Kogure, S. Wongseripipatana, H. Takayama

DOI: 10.1016/j.tet.2014.10.002

CrossRef

[	NS	]	Kopsia jasminiflora
[	mp	]
[	bp	]
[	α	] D	- 66   [ MeOH ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]

Alkaloids

Vinmajine F

C20H22N2O3 = 338

Tetrahedron 2014, 70, 8723

G.-G. Cheng, Y.-L. Zhao, Y. Zhang, P.-K. Lunga, D.-B. Hu, Y. Li, J. Gu, C.-W. Song, W.-B. Sun, Y.-P. Liu, X.-D. Luo

DOI: 10.1016/j.tet.2014.09.026

CrossRef

[	NS	]	Vinca major
[	mp	]
[	bp	]
[	α	] D	+ 55.9   [ MeOH ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	cytotoxicity against A-549

Alkaloids

Alstoscholarisine D

C20H24N2O3 = 340

Org. Lett. 2014, 16, 5808

X.-W. Yang, C.-P. Yang, L.-P. Jiang, X.-J. Qin, Y.-P. Liu, Q.-S. Shen, Y.-B. Chen, X.-D. Luo

DOI: 10.1021/ol5029223

CrossRef

[	NS	]	Alstonia scholaris
[	mp	]
[	bp	]
[	α	] D	- 148.5   [ MeOH ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	promoting effect on adult neuronal stem cell proliferation

Alkaloids

Kopsine, Na-Demethoxycarbonyl-12-methoxy-

C21H24N2O3 = 352

Tetrahedron 2014, 70, 9099

M. Kitajima, M. Anbe, N. Kogure, S. Wongseripipatana, H. Takayama

DOI: 10.1016/j.tet.2014.10.002

CrossRef

[	NS	]	Kopsia jasminiflora
[	mp	]
[	bp	]
[	α	] D	- 12   [ CHCl3 ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]

Alkaloids

Kopsinilam, 16-epi-

C21H24N2O3 = 352

Tetrahedron 2014, 70, 9099

M. Kitajima, M. Anbe, N. Kogure, S. Wongseripipatana, H. Takayama

DOI: 10.1016/j.tet.2014.10.002

CrossRef

[	NS	]	Kopsia jasminiflora
[	mp	]
[	bp	]
[	α	] D	+ 72   [ CHCl3 ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]

Alkaloids

Vobasidine B

C21H24N2O3 = 352

J. Nat. Prod. 2014, 77, 2504

D. S.-Y. Sim, K.-W. Chong, C.-E Nge, Y.-Y. Low, K.-S. Sim, T.-S. Kam

DOI: 10.1021/np500589u

CrossRef

[	NS	]	Tabernaemontana
[	mp	]
[	bp	]
[	α	] D	- 142   [ CHCl3 ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	cytotoxicity

Alkaloids

Alstoscholarisine B

C21H26N2O3 = 354

Org. Lett. 2014, 16, 5808

X.-W. Yang, C.-P. Yang, L.-P. Jiang, X.-J. Qin, Y.-P. Liu, Q.-S. Shen, Y.-B. Chen, X.-D. Luo

DOI: 10.1021/ol5029223

CrossRef

[	NS	]	Alstonia scholaris
[	mp	]	168 - 169 ℃
[	bp	]
[	α	] D	- 162.3   [ MeOH ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	promoting effect on adult neuronal stem cell proliferation

Alkaloids

Alstoscholarisine C

C21H26N2O3 = 354

Org. Lett. 2014, 16, 5808

X.-W. Yang, C.-P. Yang, L.-P. Jiang, X.-J. Qin, Y.-P. Liu, Q.-S. Shen, Y.-B. Chen, X.-D. Luo

DOI: 10.1021/ol5029223

CrossRef

[	NS	]	Alstonia scholaris
[	mp	]	98 - 101 ℃
[	bp	]
[	α	] D	- 213.3   [ MeOH ]
[	Ph	]	uv Hnmr Cnmr ir Xray mass cd syn
[	act	]	promoting effect on adult neuronal stem cell proliferation

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