Regular Issue

Vol. 9, No. 6, 1978

6 data found. 1 - 6 listed
Communication | Regular issue | Vol 9, No. 6, 1978, pp. 727 - 730
Published online:
DOI: 10.3987/R-1978-06-0727
Studies on the Synthesis of 13-Methyltetrahydroprotoberberine Derivative

Hideo Iida,* Mamoru Narimiya, Nobuko Katoh, Hiroji Ina, and Toyohiko Kikuchi

*Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan


4-Methylated isocarbostyril derivative (VII) was reduced with lithium aluminum hydride, followed by an acidic treatment to give the trans-13-methyltetrahydroprotoberberine (VIII).

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Communication | Regular issue | Vol 9, No. 6, 1978, pp. 731 - 738
Published online:
DOI: 10.3987/R-1978-06-0731
The Syntheses of Azatropolones

Takehiro Sano,* Yoshie Horiguchi, and Yoshisuke Tsuda

*Showa Pharmaceutical University, 3-3165, Higashi-tamagawagakuen, Machida, Tokyo 194-8543, Japan


Azatropolones, the compounds of new ring system, were synthesized by thermal cleavage of 2-azabicyclo[3.2.0]hept-6-one derivatives, and their chemical and spectral properties were described. Particularly azatropolones were susceptible to solvolysis furnishing pyridine-2-carboxylates.

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Communication | Regular issue | Vol 9, No. 6, 1978, pp. 739 - 744
Published online:
DOI: 10.3987/R-1978-06-0739
Ring Transformation of Uracils to 2-Pyridones. Hydrolysis of 6-(2-Dimethylaminovinyl)uracils

Shigeo Senda,* Kosaku Hirota, Tetsuji Asao, and Yoshio Abe

*Gifu Pharmaceutical University, 6-1 Mitahora-higashi 5-chome, Gifu 502-8585, Japan


Hydrolysis of 1,3-disubstituted 6-(2-dimethylaminovinyl)uracil derivatives (I) in aqueous sodium hydroxide caused a novel ring transformation giving 2-pyridone (II) along with 4-methylenepyrimidine (III) or the degradation product (IV or V).

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Communication | Regular issue | Vol 9, No. 6, 1978, pp. 745 - 752
Published online:
DOI: 10.3987/R-1978-06-0745
Kuwanon D, New Isoprenoid Flavanone from the Root Bark of the Cultivated Mulberry Tree (Morus Alba L.)

Taro Nomura,* Toshio Fukai, and Masa Katayanagi

*School of Pharmaceutical Sciences, Toho University, 2-2-1, Miyama, Funabashi, Chiba 274-8510, Japan


From the benzene extract of the root bark of the cultivated mulberry tree (a variety of Morus alba L.), a novel isoprene-substituted flavanone, kuwanon D, was isolated whose structure was shown to be I on the basis of spectral data.

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Communication | Regular issue | Vol 9, No. 6, 1978, pp. 753 - 756
Published online:
DOI: 10.3987/R-1978-06-0753
Synthesis of D-Isoepiallomuscarine

Pen-Chung Wang, Zenon Lysenko, and Madeleine M. Joullié*

*Department of Chemistry, University of Pennsylvania, 231 South 34th Street Philadelphia, PA 19104-6323, U.S.A.


D-Isoepiallomuscarine is prepared in high yield from α-D-glucose by way of regio-, and stereo-selective epoxide ring opening using sodium phenyl selenide.

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Communication | Regular issue | Vol 9, No. 6, 1978, pp. 757 - 761
Published online:
DOI: 10.3987/R-1978-06-0757
Reaction of Enamine Esters with Diazonium Salts. A Facile One-Pot Synthesis of Imidazo[1,2a]azacycloalkanes

Chananjah B. Kanner and Upendra K. Pandit*

*Organic Chemistry Laboratory, University of Amsterdam, Nieuwe Achtergracht 129, 1018 WS Amsterdam, The Netherlands


Reaction of β-aminoacrylic esters with benzenediazonium fluoroborate, followed by treatment with triethyl amine leads to the formation of imidazole derivatives.

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6 data found. 1 - 6 listed