Regular Issue

Vol. 26, No. 12, 1987

34 data found. 31 - 34 listedFirst Previous
Paper | Regular issue | Vol 26, No. 12, 1987, pp. 3239 - 3248
Published online:
DOI: 10.3987/R-1987-12-3239
Heterocycles. XXI. Liquid Chromatographic Optical Resolution of Racemic Chalcone Epoxides and Flavanonols

Hiroshi Takahashi, Shaoshun Li, Yoshihiro Harigaya, and Masayuki Onda

*School of Pharmaceutical Sciences, Kitasato University, 5-9-1, Shirokane, Minato-ku, Tokyo 108-8641, Japan


Racemic chalcone epoxides and flavanonols have been separated into their enantiomers by hplc on a Chiralpack OT(+) column using methanol as the eluent.

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Paper | Regular issue | Vol 26, No. 12, 1987, pp. 3249 - 3257
Published online:
DOI: 10.3987/R-1987-12-3249
Reactions of 2-Acylpyridine 1-Oxides with Acid Anhydrides

Hiroyuki Nagano and Masatomo Hamana

*Central Research Laboratories, Chugai Pharmaceutical Company, Ltd., Takada 3-41-8, Toshima-ku, Tokyo 171, Japan


Treatment of 2-acetyl- and 2-propionyl-pyridine 1-oxides (1a and 1b) with hot acetic, propionic and benzoic anhydrides initially gives the respective enol acylates (A), which further undergo deoxygenative β-acyloxylation to give enediol diacylates (E) and ketol esters (F).

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Paper | Regular issue | Vol 26, No. 12, 1987, pp. 3259 - 3264
Published online:
DOI: 10.3987/R-1987-12-3259
Studies on as-Triazine Derivatives. VIII. Synthesis of 5-Substituted 1,2,4-Triazines

Shoetsu Konno, Setsuya Ohba, Mitsuko Agata, Yuichi Aizawa, Mataichi Sagi, and Hiroshi Yamanaka

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan


Dehydroxy-chlorination of 6-methyl-3-phenyl-(3a),and 3,6-diphenyl-5-oxo-2,5-dihydro-1,2,4-triazine (3b) afforded the corresponding 5-chloro-1,2,4-triazines (4a,b). The chloro-1,2,4-triazines (4a,b) treated with sodium alkoxides or amines to give the 5-alkoxy- (5a,b), or 5-amino (6a,b) derivatives. Furthermore, 4 readily reacted not only with active methylene compounds but also with acetophenone and nitromethane under basic conditions.

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Review | Regular issue | Vol 26, No. 12, 1987, pp. 3265 - 3284
Published online:
DOI: 10.3987/R-1987-12-3265
Synthesis of Azamodified Adamantane Derivatives via Bridgehead- and Bridge Imines. A New Aspect in the Chemistry of Heteroadamantane Derivatives

Shoji Eguchi, Takashi Okano, and Hisato Takeuchi

*Faculty of Engineering, Nagoya University, Chikusa, Nagoya, Aichi 464-8601, Japan


Recent advances in the chemistry of heteroadamantane derivatives, in particular synthesis and reactions of azamodified adamantane derivatives, have been reviewed emphasizing the synthetic utility of bridgehead imines as well as bridge

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