Special Issue

Gilbert Stork's Special Issues, Vol. 25, No. 1, 1987

96 data found. 91 - 96 listedFirst Previous
Review | Special issue | Vol 25, No. 1, 1987, pp. 617 - 640
Published online:
DOI: 10.3987/S-1987-01-0617
Studies in Plant Tissue Sulture. The Synthesis and Biosynthesis of Indole Alkaloids

James P. Kutney

*Department of Chemistry, The University of British Columbia, 2036 Main Mall, Vancouver, B.C., V6T 1Z1, Canada


A summary of recent studies with various plant tissue cultures obtained from Catharanthus roseus is presented. The main emphasis of the research program concerns the propagation of stable cell lines for the production of the alkaloids catharanthine, vinblastine and vincristine. Related to these objectives are studied on the biosynthesis and biotransformation of 3’,4’-anhydrovinblastine (26) in order to provide a better understanding of the enzymatic production of the above-mentioned bisindole alkaloids. Isolation of cell free extracts (crude enzyme mixtures) from such cultures and studies with these extracts are also presented.

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Review | Special issue | Vol 25, No. 1, 1987, pp. 641 - 657
Published online:
DOI: 10.3987/S-1987-01-0641
Hydroboration of Heterocycles Olefins — A Versatile Route for the Synthesis of Both Racemic and Optically Active Heterocyclic Compounds

Herbert C. Brown and J. V. N. Vara Prasad

*Richard B. Wetherill Laboratory, Purdue University, West Lafayette, Indiana 47907-1393, U.S.A.


The hydroboration of representative types of heterocyclic olefins with various hydroborating agents, viz., borane-methyl sulfide, 9-borabicyclo[3.3.1]nonane, dicyclohexylborane and disiamylborane, is described. The synthesis of heterocyclic derivatives of high enantiomeric purity via asymmetric hydroboration of heterocyclic olefins with chiral hydroborating agents is also reviewed. The preparation and isolation of heterocyclic boronates of essentially 100% ee is also discussed, as well as the probable range of utilization of these derivatives for the asymmetric synthesis of optically pure enantiomeric heterocyclic derivatives.

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Review | Special issue | Vol 25, No. 1, 1987, pp. 659 - 700
Published online:
DOI: 10.3987/S-1987-01-0659
Syntheses of Indolizidine Alkaloids — A Review

Sundaramoorthi Rajeswari, Sundaram Chandrasekharan, and Tuticorin R. Govindachari

*Research and Development Laboratory, Amrutanjan Limited, Mylapore, Madras-600 004, India


Synthetic approaches to the indolizidine alkaloids as well as chiral syntheses of some members of this group published during 1979-1985 are reviewed.

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Review | Special issue | Vol 25, No. 1, 1987, pp. 701 - 728
Published online:
DOI: 10.3987/S-1987-01-0701
Review of Synthetic Studies toward CC-1065, PDE-I, and PDE-II

Viresh H. Rawal, Robert J. Jones, and Michael P. Cava

*Department of Chemistry, University of Alabama, Box 870336, University, Tuscaloosa, Alabama 35478-0336, U.S.A.


The synthetic approaches to the potent antitumor agent CC-1065 (1) and the closely related phosphodiesterase inhibitors PDE-I (2) and PDE-II (3) are reviewed.

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Review | Special issue | Vol 25, No. 1, 1987, pp. 729 - 806
Published online:
DOI: 10.3987/S-1987-01-0729
Enantioselective Syntheses of Carbapenem Antibiotics

Takayasu Nagahara and Tetsuji Kametani

*Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan


A family of carbapenem antibiotics, represented by thienamycin, exhibits strong and broad antibacterial activities. In this review, recent enantioselectlve syntheses of naturally occurring carbapenems are summarized as a main subject.

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Review | Special issue | Vol 25, No. 1, 1987, pp. 807 - 841
Published online:
DOI: 10.3987/S-1987-01-0807
Advances in the Chemistry of the Furanoditerphenoids from Teucrium Species

Franco Piozzi, Benjamin Rodriguez, and Giuseppe Savona

*Dipartimento di Chimica Organica, Università digli Studi di Palermo, Via Archirafi 20 90123 Palermo, Italy


This reviev describes the major advances reported during the last five years on the chemistry of these diterpenoids.

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96 data found. 91 - 96 listedFirst Previous