Regular Issue

Vol. 23, No. 8, 1985

38 data found. 31 - 38 listedFirst Previous
Report | Regular issue | Vol 23, No. 8, 1985, pp. 2041 - 2043
Published online:
DOI: 10.3987/R-1985-08-2041
Reaction of Pyridinium Bis(methoxycarbonyl)methylid with Diphenylcyclopropenethione: A Revised Structure for One of the Products

Kiyoshi Matsumoto,* Takane Uchida, Yoshiko Yagi, Hiroshi Tahara, and R. Morrin Acheson

*Graduate School of Human and Environmental Studies, Kyoto University, Yoshida-Nihonmatsu-cho, Sakyo-ku, Kyoto 606-8501, Japan


A structure for one product from the reaction of pyridinium bis(methoxycarbonyl)methylid and diphenylcyclopropanethione is revised to be 5,5-bis(methoxycarbonyl)-2,3,6,7-tetraphenyl-5H-thieno[2,3-e]thiopyrane.

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Report | Regular issue | Vol 23, No. 8, 1985, pp. 2045 - 2050
Published online:
DOI: 10.3987/R-1985-08-2045
The Chemical Reactivitu of 2,2,3,3-Tetramethyl-1-aziridinecarboximidate

Sang-Hun Jung and Harold Kohn*

*Department of Chemistry, University of Houston, Houston, TX 77004, U.S.A.


The activated aziridine, 2,2,3,3-tetramethyl-1-aziridinecarboximidate, does not rearrange to the corresponding 4,5-dihydro-4,4,5,5-tetramethyl-2-ethoxyimidazole in the presence of either nucleophilic catalysts or acids, rather the major products obtained were ring-opened adducts. The mechanism of these atypical transformations are discussed.

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Report | Regular issue | Vol 23, No. 8, 1985, pp. 2051 - 2056
Published online:
DOI: 10.3987/R-1985-08-2051
Novel Fused-Ring Derivatives of 1,4-Benzodiazepine System: Synthesis of Tetrahydro-1H-triazolo[4,3-d][1,4]benzodiazepines

Giuseppe Capozzi, Alba Chimirri, Silvana Grasso, Giovanni Romeo,* and Giovanni Zappia

*Dipartimento Farmaco-Chimico, Università di Messina, Viale Annunziata, 98168 Messina, Italy


A novel class of annelated 1,4-benzodiazepines is synthesized by 1,3-dipolar cycloaddition of suitable nitrilimines to the C=N bond of the benzodiazepine ring. Structures and conformations of adducts have been assigned by means of spectroscopic measurements. The additional heterocyclic nucleus has been found to influence dramatically the conformational mobility of the heptatomic ring.

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Report | Regular issue | Vol 23, No. 8, 1985, pp. 2057 - 2064
Published online:
DOI: 10.3987/R-1985-08-2057
Reactions of Uracils 9. Synthesis and Reactions of 6-Substituted Benzylamino-5-(ethoxycarbonylethenyl)-1,3-dimethyluracils

Péter Mátyus,* László Löwinger, and Heinrich Wamhoff

*Institute for Drug Research Ltd., H-1325 Budapest, POB 82, Hungary


Starting from 6-chloro-5-(2-ethoxycarbonylethenyl)-1,3-dimethyluracil the novel 6-substituted benzylamino derivatives 1c-f were synthesized which gave either 2,4,7-trioxopyrido[2,3-d]pyrimidines 2c-e or the 6-substituted benzylidenamino analogues 3c-f depending on the reaction conditions. A kinetic study was also carried out.

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Report | Regular issue | Vol 23, No. 8, 1985, pp. 2065 - 2067
Published online:
DOI: 10.3987/R-1985-08-2065
Preparation and Thermal Properyies of 2-Aryl-5-benzoylthio-1,3,4-oxadiazoles

Yasuo Saegusa,* Norihiko Akano, Shigeo Nakamura, Nguyen Chau, and Yoshio Iwakura

*Faculty of Technology, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama 221-8686, Japan


Novel type of thioesters, 2-aryl-S-benzoylthio-1,3,4-oxadiazoles (3a-3d), were prepared by the elaborate benzoylation of 2-aryl-1,3,4-oxadiazoline-5-thiones (1a-1d), and their thermal behavior was elucidated by differential thermal analysis (DTA).

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Report | Regular issue | Vol 23, No. 8, 1985, pp. 2069 - 2074
Published online:
DOI: 10.3987/R-1985-08-2069
Synthesis of Novel 6-Substitutued 2-Chloro-3-methylquinoxalines

Kenji Makino,* Gozyo Sakata, and Katsushi Morimoto

*Central Research Institute, Nissan Chemical Industries Ltd., 722-1 Tsuboicho, Funabashi, Chiba 274-8507, Japan


Facile synthesis of novel 6-substituted 2-chloro-3-methylquinoxalines (4a-d) is described. Intramolecular cyclization reaction of 4-substituted 2-nitroacetoacetanilides (1a-d) in basic conditions affordaed 6-substituted 2(1H)-quinoxalinone-4-oxides (2a-d) and in situ, which could be converted into novel 6-substituted 3-methyl-2(1H)-quinoxalinones (3a-d) using ethyl acetoacetate. 3a-d were chlorinated with phosphoryl chloride to afford 4a-d.

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Report | Regular issue | Vol 23, No. 8, 1985, pp. 2075 - 2081
Published online:
DOI: 10.3987/R-1985-08-2075
Constituents of West African Medical Plants. XVIII. The Annoidines — A New Class of Prenylated Bisindole Alkaloids from Annonidium mannii

Hans Achenbach* and Christian Renner

*Institute of Pharmacy, Department of Pharmaceutical Chemistry, University of Erlangen, D-8520 Erlangen, Germany


From the stem bark of Annonidium mannii annonidines A - E (3 - 7) have been isolated and their structures determined. 3 to 7 belong to a new structural type of prenylated bisindole alkaloids.

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Review | Regular issue | Vol 23, No. 8, 1985, pp. 2083 - 2119
Published online:
DOI: 10.3987/R-1985-08-2083
Recent Progress in the Quinoline Chemistry: Utility of 3-Alkoxycarbonylmethylene-2-oxo-1,2,3,4-tetrahydroquinoxalines as Starting Materials

Yoshihisa Kurasawa* and Atsushi Takada

*School of Pharmaceutical Sciences, Kitasato University, Shirokane, Minato-ku, Tokyo 108-8641, Japan


3-Alkoxycarbonylmethylene-2-oxo-1,2,3,4-tetrahydroquinoxalines 1 have been converted into various quinoxaline derivatives via versatile intermediates by the facile synthetic methods. This review describes these synthetic routes, including the mechanistic considerations and the spectroscopic properties.

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38 data found. 31 - 38 listedFirst Previous